Wilson Reservoir is located in northern Alabama near the towns of Florence and Muscle Shoals. The reservoir extends upstream for 15 miles to Wheeler Dam and covers 15,500 acres.

Largemouth bass, smallmouth bass and catfish are targeted most often by anglers on Wilson Lake. No minimum size limit is effect for largemouth bass and spotted bass, and the minimum length limit for smallmouth bass is 14-inches.

During the fall, smallmouth bass congregate in the tailwaters of Wheeler Dam. Most anglers drift live threadfin shad, locally called yellowtails, in the swift current for trophy smallmouths. Other species that congregate below Wheeler Dam are hybrid and saltwater striped bass in the spring, sauger in the winter, and blue catfish and channel catfish during the summer. This area is very popular with both boats and bank anglers. A fishing platform directly below the dam is convenient for bank anglers.